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KMID : 1007320110170020075
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Journal of the Korean Society of Menopause
2011 Volume.17 No. 2 p.75 ~ p.80
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Serum Concentration of Estradiol and Estrone Following Oral Administration of Low-dose Hormone Therapy in Postmenopausal Korean Women
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Lee Eun-Ju
Lee Byung-Seok
Kang Byung-Moon
Yoon Byung-Koo
Choi Hoon
Kim Jung-Gu
Park Hyoung-Moo
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Abstract
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Objectives: To determine the baseline serum concentrations of estradiol and estrone in postmenopausal Korean women and the serum concentrations of estradiol and estrone after 4 and 16 weeks of treatment using 1 mg of estradiol and 2 mg of drospirenone.
Methods:This was a multicenter study. Thirty-six subjects were screened. Serum estradiol, estrone and drospirenone levels were determined by gas chromatography-mass spectrometry and radioimmunoassay.
Results: The mean estradiol concentration was 8.37 ± 12.1 pg/mL at baseline and increased to 53.7 ± 52.1 and 41.4 ± 26.1 pg/mL after 4 and 16 weeks of treatment, respectively. The mean estrone concentrations were 28.7 ± 26.8, 266.1 ± 182.9, and 256.1 ± 179.1 pg/mL at baseline, and after 4 and 16 weeks of treatment, respectively. When women were stratified according to the basal estradiol level, the level after 4 weeks of treatment was significantly higher in the women with a detectable level (≥ 5 pg/mL) than in women with an undetectable level (＜ 5 pg/mL; 65.2 ± 21.5 vs. 37.4 ± 25.8 pg/mL, P = 0.008). After 16 weeks of treatment, the estradiol level was still higher in the detectable group (51.6 ± 28.6 vs. 38.7 ± 21.7 pg/mL, P = 0.09).
Conclusion: This study showed that 1 mg of estradiol and 2 mg of drospirenone is an appropriate regimen to achieve the desired serum estradiol level. The difference in serum hormonal levels after 4 weeks of treatment could be caused by different basal levels.
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KEYWORD
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Drospirenone, Estradiol, Estrogen replacement therapy, Estrone, Postmenopause
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